Design of Trypanosoma rangeli sialidase mutants with improved trans-sialidase activity

A sialidase (EC 3.2.1.18) from the non-pathogenic Trypanosoma rangeli, TrSA, has been shown to exert trans-sialidase activity after mutation of five specific amino acids in the active site (M96V, A98P, S120Y, G249Y, Q284P) to form the so-called TrSA(5mut) enzyme. By computational and hypothesis driv...

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Detalles Bibliográficos
Autores principales: Nyffenegger, Christian, Nordvang, Rune Thorbjørn, Jers, Carsten, Meyer, Anne S., Mikkelsen, Jørn Dalgaard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291517/
https://www.ncbi.nlm.nih.gov/pubmed/28158299
http://dx.doi.org/10.1371/journal.pone.0171585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291517/
https://www.ncbi.nlm.nih.gov/pubmed/28158299
http://dx.doi.org/10.1371/journal.pone.0171585

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