Paclitaxel-resistant cancer cell-derived secretomes elicit ABCB1-associated docetaxel cross-resistance and escape from apoptosis through FOXO3a-driven glycolytic regulation

Chemotherapy-induced cancer cell secretomes promote resistance due, in part, to a predominant glycolytic energy metabolism, which drives aggressive cancer cell proliferation. However, the characterization of these secretomes and the molecular events that associate them with acquired drug resistance...

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Detalles Bibliográficos
Autores principales: Aldonza, Mark Borris D, Hong, Ji-Young, Lee, Sang Kook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291837/
https://www.ncbi.nlm.nih.gov/pubmed/28104912
http://dx.doi.org/10.1038/emm.2016.131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291837/
https://www.ncbi.nlm.nih.gov/pubmed/28104912
http://dx.doi.org/10.1038/emm.2016.131

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