Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

VEGF signaling through VEGFR2 is a central regulator of the angiogenic response. Inhibition of VEGF signaling by the stress-induced matricellular protein TSP1 plays a role in modulating the angiogenic response to VEGF in both health and disease. TSP1 binding to CD47 inhibits VEGFR2 activation. The f...

Descripción completa

Detalles Bibliográficos
Autores principales: Bazzazi, Hojjat, Isenberg, Jeffery S., Popel, Aleksander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292565/
https://www.ncbi.nlm.nih.gov/pubmed/28220078
http://dx.doi.org/10.3389/fphys.2017.00048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292565/
https://www.ncbi.nlm.nih.gov/pubmed/28220078
http://dx.doi.org/10.3389/fphys.2017.00048

Ejemplares similares