A phase I, open-label, dose-escalation, multicenter study of the JAK2 inhibitor NS-018 in patients with myelofibrosis

NS-018 is a Janus-activated kinase 2 (JAK2)-selective inhibitor, targeting the JAK–signal transducer and activator of transcription (STAT) pathway that is deregulated in myelofibrosis. In this phase I, dose-escalation portion of a phase I/II study, patients with myelofibrosis received oral NS-018 in...

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Detalles Bibliográficos
Autores principales: Verstovsek, S, Talpaz, M, Ritchie, E, Wadleigh, M, Odenike, O, Jamieson, C, Stein, B, Uno, T, Mesa, R A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292677/
https://www.ncbi.nlm.nih.gov/pubmed/27479177
http://dx.doi.org/10.1038/leu.2016.215

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292677/
https://www.ncbi.nlm.nih.gov/pubmed/27479177
http://dx.doi.org/10.1038/leu.2016.215

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