Prediction of CYP2D6 phenotype from genotype across world populations

PURPOSE: Owing to its highly polymorphic nature and major contribution to the metabolism and bioactivation of numerous clinically used drugs, CYP2D6 is one of the most extensively studied drug-metabolizing enzymes and pharmacogenes. CYP2D6 alleles confer no, decreased, normal, or increased activity...

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Detalles Bibliográficos
Autores principales: Gaedigk, Andrea, Sangkuhl, Katrin, Whirl-Carrillo, Michelle, Klein, Teri, Leeder, J. Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292679/
https://www.ncbi.nlm.nih.gov/pubmed/27388693
http://dx.doi.org/10.1038/gim.2016.80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292679/
https://www.ncbi.nlm.nih.gov/pubmed/27388693
http://dx.doi.org/10.1038/gim.2016.80

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