Enhancing the biocatalytic manufacture of the key intermediate of atorvastatin by focused directed evolution of halohydrin dehalogenase

Halohydrin dehalogenases (HHDHs) are biocatalytically interesting enzymes due to their ability to form C-C, C-N, C-O, and C-S bonds. One of most important application of HHDH was the protein engineering of HheC (halohydrin dehalogenase from Agrobacterium radiobacter AD1) for the industrial manufactu...

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Detalles Bibliográficos
Autores principales: Luo, Yu, Chen, Yangzi, Ma, Hongmin, Tian, ZhenHua, Zhang, Yeqi, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292711/
https://www.ncbi.nlm.nih.gov/pubmed/28165015
http://dx.doi.org/10.1038/srep42064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292711/
https://www.ncbi.nlm.nih.gov/pubmed/28165015
http://dx.doi.org/10.1038/srep42064

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