Coenzyme Q(10) partially restores pathological alterations in a macrophage model of Gaucher disease

BACKGROUND: Gaucher disease (GD) is caused by mutations in the GBA1 gene which encodes lysosomal β-glucocerebrosidase (GCase). In GD, partial or complete loss of GCase activity causes the accumulation of the glycolipids glucosylceramide (GlcCer) and glucosylsphingosine in the lysosomes of macrophage...

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Detalles Bibliográficos
Autores principales: de la Mata, Mario, Cotán, David, Oropesa-Ávila, Manuel, Villanueva-Paz, Marina, de Lavera, Isabel, Álvarez-Córdoba, Mónica, Luzón-Hidalgo, Raquel, Suárez-Rivero, Juan M., Tiscornia, Gustavo, Sánchez-Alcázar, José A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292786/
https://www.ncbi.nlm.nih.gov/pubmed/28166796
http://dx.doi.org/10.1186/s13023-017-0574-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292786/
https://www.ncbi.nlm.nih.gov/pubmed/28166796
http://dx.doi.org/10.1186/s13023-017-0574-8

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