A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma

BACKGROUND: We have identified molecules that exhibit synthetic lethality in cells with loss of the neurofibromin 1 (NF1) tumor suppressor gene. However, recognizing tumors that have inactivation of the NF1 tumor suppressor function is challenging because the loss may occur via mechanisms that do no...

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Detalles Bibliográficos
Autores principales: Way, Gregory P., Allaway, Robert J., Bouley, Stephanie J., Fadul, Camilo E., Sanchez, Yolanda, Greene, Casey S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292791/
https://www.ncbi.nlm.nih.gov/pubmed/28166733
http://dx.doi.org/10.1186/s12864-017-3519-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292791/
https://www.ncbi.nlm.nih.gov/pubmed/28166733
http://dx.doi.org/10.1186/s12864-017-3519-7

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