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A machine learning classifier trained on cancer transcriptomes detects NF1 inactivation signal in glioblastoma
BACKGROUND: We have identified molecules that exhibit synthetic lethality in cells with loss of the neurofibromin 1 (NF1) tumor suppressor gene. However, recognizing tumors that have inactivation of the NF1 tumor suppressor function is challenging because the loss may occur via mechanisms that do no...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292791/ https://www.ncbi.nlm.nih.gov/pubmed/28166733 http://dx.doi.org/10.1186/s12864-017-3519-7 |