Drug trapping in hERG K(+) channels: (not) a matter of drug size?

Inhibition of hERG K(+) channels by structurally diverse drugs prolongs the ventricular action potential and increases the risk of torsade de pointes arrhythmias and sudden cardiac death. The capture of drugs behind closed channel gates, so-called drug trapping, is suggested to harbor an increased p...

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Detalles Bibliográficos
Autores principales: Linder, Tobias, Bernsteiner, Harald, Saxena, Priyanka, Bauer, Florian, Erker, Thomas, Timin, Eugen, Hering, Steffen, Stary-Weinzinger, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292991/
https://www.ncbi.nlm.nih.gov/pubmed/28337337
http://dx.doi.org/10.1039/c5md00443h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292991/
https://www.ncbi.nlm.nih.gov/pubmed/28337337
http://dx.doi.org/10.1039/c5md00443h

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