DNA Vaccine Encoding HPV16 Oncogenes E6 and E7 Induces Potent Cell-mediated and Humoral Immunity Which Protects in Tumor Challenge and Drives E7-expressing Skin Graft Rejection

We have previously shown that a novel DNA vaccine technology of codon optimization and the addition of ubiquitin sequences enhanced immunogenicity of a herpes simplex virus 2 polynucleotide vaccine in mice, and induced cell-mediated immunity when administered in humans at relatively low doses of nak...

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Detalles Bibliográficos
Autores principales: Chandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., R. Leggatt, Graham, Finlayson, Neil, Frazer, Ian H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2017
Materias:
Basic Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293162/
https://www.ncbi.nlm.nih.gov/pubmed/28166181
http://dx.doi.org/10.1097/CJI.0000000000000156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293162/
https://www.ncbi.nlm.nih.gov/pubmed/28166181
http://dx.doi.org/10.1097/CJI.0000000000000156

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