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Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localization

Serine/arginine protein kinases (SRPKs) phosphorylate Arg/Ser dipeptide-containing proteins that play crucial roles in a broad spectrum of basic cellular processes. The existence of a large internal spacer sequence that separates the bipartite kinase catalytic core is a unique structural feature of...

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Detalles Bibliográficos
Autores principales: Koutroumani, Maria, Papadopoulos, Georgios E., Vlassi, Metaxia, Nikolakaki, Eleni, Giannakouros, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293202/
https://www.ncbi.nlm.nih.gov/pubmed/28166275
http://dx.doi.org/10.1371/journal.pone.0171328