A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice

Monospermic fertilization is mediated by the extracellular zona pellucida composed of ZP1, ZP2 and ZP3. Sperm bind to the N-terminus of ZP2 which is cleaved after fertilization by ovastacin (encoded by Astl) exocytosed from egg cortical granules to prevent sperm binding. Astl(Null) mice lack the pos...

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Detalles Bibliográficos
Autores principales: Xiong, Bo, Zhao, Yangu, Beall, Stephanie, Sadusky, Anna Burkart, Dean, Jurrien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293279/
https://www.ncbi.nlm.nih.gov/pubmed/28114310
http://dx.doi.org/10.1371/journal.pgen.1006580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293279/
https://www.ncbi.nlm.nih.gov/pubmed/28114310
http://dx.doi.org/10.1371/journal.pgen.1006580

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