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A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice
Monospermic fertilization is mediated by the extracellular zona pellucida composed of ZP1, ZP2 and ZP3. Sperm bind to the N-terminus of ZP2 which is cleaved after fertilization by ovastacin (encoded by Astl) exocytosed from egg cortical granules to prevent sperm binding. Astl(Null) mice lack the pos...
Autores principales: | Xiong, Bo, Zhao, Yangu, Beall, Stephanie, Sadusky, Anna Burkart, Dean, Jurrien |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293279/ https://www.ncbi.nlm.nih.gov/pubmed/28114310 http://dx.doi.org/10.1371/journal.pgen.1006580 |
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