High Affinity vs. Native Fibronectin in the Modulation of αvβ3 Integrin Conformational Dynamics: Insights from Computational Analyses and Implications for Molecular Design

Understanding how binding events modulate functional motions of multidomain proteins is a major issue in chemical biology. We address several aspects of this problem by analyzing the differential dynamics of αvβ3 integrin bound to wild type (wtFN10, agonist) or high affinity (hFN10, antagonist) muta...

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Detalles Bibliográficos
Autores principales: Paladino, Antonella, Civera, Monica, Belvisi, Laura, Colombo, Giorgio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293283/
https://www.ncbi.nlm.nih.gov/pubmed/28114375
http://dx.doi.org/10.1371/journal.pcbi.1005334

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293283/
https://www.ncbi.nlm.nih.gov/pubmed/28114375
http://dx.doi.org/10.1371/journal.pcbi.1005334

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