Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases

Receptor tyrosine kinase (RTK) signaling is tightly regulated by protein allostery within the intracellular tyrosine kinase domains. Yet the molecular determinants of allosteric connectivity in tyrosine kinase domain are incompletely understood. By means of structural (X-ray and NMR) and functional...

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Detalles Bibliográficos
Autores principales: Chen, Huaibin, Marsiglia, William M, Cho, Min-Kyu, Huang, Zhifeng, Deng, Jingjing, Blais, Steven P, Gai, Weiming, Bhattacharya, Shibani, Neubert, Thomas A, Traaseth, Nathaniel J, Mohammadi, Moosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293489/
https://www.ncbi.nlm.nih.gov/pubmed/28166054
http://dx.doi.org/10.7554/eLife.21137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293489/
https://www.ncbi.nlm.nih.gov/pubmed/28166054
http://dx.doi.org/10.7554/eLife.21137

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