A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms

It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways pre-configured to activate in response to a dangerous low cell [Mg(++)] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. L...

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Detalles Bibliográficos
Autor principal: van Woerkom, Arthur Ernst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293501/
https://www.ncbi.nlm.nih.gov/pubmed/28203080
http://dx.doi.org/10.2147/NDT.S123612
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author van Woerkom, Arthur Ernst
author_facet van Woerkom, Arthur Ernst
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description It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways pre-configured to activate in response to a dangerous low cell [Mg(++)] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg(++)] level.
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spelling pubmed-52935012017-02-15 A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms van Woerkom, Arthur Ernst Neuropsychiatr Dis Treat Hypothesis It is proposed that lithium’s therapeutic effects occur indirectly by augmenting a cascade of protective “fail-safe” pathways pre-configured to activate in response to a dangerous low cell [Mg(++)] situation, eg, posttraumatic brain injury, alongside relative cell adenosine triphosphate depletion. Lithium activates cell protection, as it neatly mimics a lowered intracellular [Mg(++)] level. Dove Medical Press 2017-01-31 /pmc/articles/PMC5293501/ /pubmed/28203080 http://dx.doi.org/10.2147/NDT.S123612 Text en © 2017 van Woerkom. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Hypothesis
van Woerkom, Arthur Ernst
A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_full A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_fullStr A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_full_unstemmed A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_short A fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
title_sort fully integrated new paradigm for lithium’s mode of action – lithium utilizes latent cellular fail-safe mechanisms
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293501/
https://www.ncbi.nlm.nih.gov/pubmed/28203080
http://dx.doi.org/10.2147/NDT.S123612
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