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Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats

Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR w...

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Autores principales: Li, Bo, Yang, Zheng-Biao, Lei, Shan-Shan, Su, Jie, Pang, Min-Xia, Yin, Chao, Chen, Guo-Yang, Shan, Chao-Wen, Chen, Bo, Hu, Hui-Ming, Chen, Su-Hong, Lv, Gui-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294363/
https://www.ncbi.nlm.nih.gov/pubmed/28243310
http://dx.doi.org/10.1155/2017/5816960
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author Li, Bo
Yang, Zheng-Biao
Lei, Shan-Shan
Su, Jie
Pang, Min-Xia
Yin, Chao
Chen, Guo-Yang
Shan, Chao-Wen
Chen, Bo
Hu, Hui-Ming
Chen, Su-Hong
Lv, Gui-Yuan
author_facet Li, Bo
Yang, Zheng-Biao
Lei, Shan-Shan
Su, Jie
Pang, Min-Xia
Yin, Chao
Chen, Guo-Yang
Shan, Chao-Wen
Chen, Bo
Hu, Hui-Ming
Chen, Su-Hong
Lv, Gui-Yuan
author_sort Li, Bo
collection PubMed
description Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR were orally treated with distilled water, metoprolol (MP, 20 mg/kg), and PG (PG-H, 90 mg/kg or PG-L, 30 mg/kg) for a single time or daily for 7 weeks. The 24-hour dynamic blood pressure was monitored and then calculated BPV including long- and short-term systolic blood pressure variability (SBPV), diastolic blood pressure variability (DBPV), mean blood pressure variability (MBPV), and heart rate variability (HRV) as well as the 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP. The protective effects of PG on TOD were observed by histopathologic and biochemical detection. The results indicated that long- and short-term SBPV, DBPV, MBPV, and HRV as well as 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP showed no significant changes after single-dose administration of PG and significantly decreased after administration with PG for 7 weeks. PG could also markedly improve the damage of aorta, heart, kidney, and brain. This study suggested that PG could notably reduce BPV, stabilize blood pressure, and mitigate TOD in SHR.
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spelling pubmed-52943632017-02-27 Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats Li, Bo Yang, Zheng-Biao Lei, Shan-Shan Su, Jie Pang, Min-Xia Yin, Chao Chen, Guo-Yang Shan, Chao-Wen Chen, Bo Hu, Hui-Ming Chen, Su-Hong Lv, Gui-Yuan Evid Based Complement Alternat Med Research Article Blood pressure variability (BPV) is associated with the development and progression of severe target organ damage (TOD). This study aims to evaluate the protective effect of paeoniflorin enriched extract from Radix Paeoniae Alba (PG) on BPV and TOD in spontaneously hypertensive rats (SHR). All SHR were orally treated with distilled water, metoprolol (MP, 20 mg/kg), and PG (PG-H, 90 mg/kg or PG-L, 30 mg/kg) for a single time or daily for 7 weeks. The 24-hour dynamic blood pressure was monitored and then calculated BPV including long- and short-term systolic blood pressure variability (SBPV), diastolic blood pressure variability (DBPV), mean blood pressure variability (MBPV), and heart rate variability (HRV) as well as the 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP. The protective effects of PG on TOD were observed by histopathologic and biochemical detection. The results indicated that long- and short-term SBPV, DBPV, MBPV, and HRV as well as 24-hour-SBP, 24-hour-DBP, and 24-hour-MBP showed no significant changes after single-dose administration of PG and significantly decreased after administration with PG for 7 weeks. PG could also markedly improve the damage of aorta, heart, kidney, and brain. This study suggested that PG could notably reduce BPV, stabilize blood pressure, and mitigate TOD in SHR. Hindawi Publishing Corporation 2017 2017-01-24 /pmc/articles/PMC5294363/ /pubmed/28243310 http://dx.doi.org/10.1155/2017/5816960 Text en Copyright © 2017 Bo Li et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Bo
Yang, Zheng-Biao
Lei, Shan-Shan
Su, Jie
Pang, Min-Xia
Yin, Chao
Chen, Guo-Yang
Shan, Chao-Wen
Chen, Bo
Hu, Hui-Ming
Chen, Su-Hong
Lv, Gui-Yuan
Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats
title Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats
title_full Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats
title_fullStr Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats
title_full_unstemmed Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats
title_short Beneficial Effects of Paeoniflorin Enriched Extract on Blood Pressure Variability and Target Organ Damage in Spontaneously Hypertensive Rats
title_sort beneficial effects of paeoniflorin enriched extract on blood pressure variability and target organ damage in spontaneously hypertensive rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294363/
https://www.ncbi.nlm.nih.gov/pubmed/28243310
http://dx.doi.org/10.1155/2017/5816960
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