The Rb1 tumour suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression

The tumour suppressor gene (Rb1) is necessary for the maintenance of telomere integrity in osteoblastic cells. We now show that the compaction of telomeric chromatin and the appropriate histone modifications of telomeric DNA are both dependent upon Rb1-mediated transcription of the telomere-derived...

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Detalles Bibliográficos
Autores principales: Gonzalez-Vasconcellos, I., Schneider, R., Anastasov, N., Alonso-Rodriguez, S., Sanli-Bonazzi, B., Fernández, J. L., Atkinson, M. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294645/
https://www.ncbi.nlm.nih.gov/pubmed/28169375
http://dx.doi.org/10.1038/srep42056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294645/
https://www.ncbi.nlm.nih.gov/pubmed/28169375
http://dx.doi.org/10.1038/srep42056

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