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Mechanosensing by the nucleus: From pathways to scaling relationships

The nucleus is linked mechanically to the extracellular matrix via multiple polymers that transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some of the emerging mechanisms of nuclear mechanosensing, which range from changes in protein conformation and transcripti...

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Detalles Bibliográficos
Autores principales: Cho, Sangkyun, Irianto, Jerome, Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294790/
https://www.ncbi.nlm.nih.gov/pubmed/28043971
http://dx.doi.org/10.1083/jcb.201610042