Cargando…

Mechanism of action of trabectedin in desmoplastic small round cell tumor cells

BACKGROUND: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive disease, that can be described as a member of the family of small round blue cell tumors. The molecular diagnostic marker is the t(11;22)(p13;q12) translocation, which creates an aberrant transcription factor, EW...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uboldi, S., Craparotta, I., Colella, G., Ronchetti, E., Beltrame, L., Vicario, S., Marchini, S., Panini, N., Dagrada, G., Bozzi, F., Pilotti, S., Galmarini, C. M., D’Incalci, M., Gatta, R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294815/ https://www.ncbi.nlm.nih.gov/pubmed/28166781 http://dx.doi.org/10.1186/s12885-017-3091-1

Ejemplares similares

A systems biology approach to investigate the mechanism of action of trabectedin in a model of myelomonocytic leukemia
por: Mannarino, L, et al.
Publicado: (2018)

Increased sensitivity to platinum drugs of cancer cells with acquired resistance to trabectedin
por: Colmegna, B, et al.
Publicado: (2015)

Trabectedin, a drug acting on both cancer cells and the tumour microenvironment
por: D'Incalci, M, et al.
Publicado: (2014)

Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin
por: Bello, Ezia, et al.
Publicado: (2019)

Trabectedin and Plitidepsin: Drugs from the Sea that Strike the Tumor Microenvironment
por: Galmarini, Carlos M., et al.
Publicado: (2014)

Correction: Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin
por: Bello, Ezia, et al.
Publicado: (2020)

Antitumour activity of trabectedin in myelodysplastic/myeloproliferative neoplasms
por: Romano, Michela, et al.
Publicado: (2017)

Effectiveness of irinotecan plus trabectedin on a desmoplastic small round cell tumor patient-derived xenograft
por: Zuco, Valentina, et al.
Publicado: (2023)

Trabectedin for desmoplastic small round cell tumours: a possible treatment option?
por: Frezza, Anna Maria, et al.
Publicado: (2014)

A Systems Biology Approach to Characterize the Regulatory Networks Leading to Trabectedin Resistance in an In Vitro Model of Myxoid Liposarcoma
por: Uboldi, Sarah, et al.
Publicado: (2012)

Editorial: Trabectedin, lurbinectedin, and other marine-derived anticancer alkaloids on solid cancer: Mechanisms of action, clinical impact, and future perspectives
por: Zambelli, Alberto, et al.
Publicado: (2023)

Effects of the Anti-Tumor Agents Trabectedin and Lurbinectedin on Immune Cells of the Tumor Microenvironment
por: Allavena, Paola, et al.
Publicado: (2022)

New transcriptional-based insights into the pathogenesis of desmoplastic small round cell tumors (DSRCTs)
por: Negri, Tiziana, et al.
Publicado: (2017)

The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial–mesenchymal transition, and immune response
por: Devecchi, Andrea, et al.
Publicado: (2018)

Lurbinectedin reduces tumour-associated macrophages and the inflammatory tumour microenvironment in preclinical models
por: Belgiovine, Cristina, et al.
Publicado: (2017)

Trabectedin: A drug from the sea that strikes tumor-associated macrophages
por: Allavena, Paola, et al.
Publicado: (2013)

New activities for the anti-tumor agent trabectedin: taking two birds with one stone
por: D'Incalci, Maurizio, et al.
Publicado: (2013)

Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB
por: Camorani, Simona, et al.
Publicado: (2018)

Mismatch repair deficiency is associated with resistance to DNA minor groove alkylating agents
por: Colella, G, et al.
Publicado: (1999)

Desmoplastic Small Round Cell Tumor of Stomach
por: Abu-Zaid, Ahmed, et al.
Publicado: (2013)

Desmoplastic small-round-cell rectal tumor
por: Gomes, Rachel M., et al.
Publicado: (2015)

Mediastinal desmoplastic small round cell tumor
por: Jin, Dacheng, et al.
Publicado: (2020)

Intra-abdominal desmoplastic small round cell tumor.
por: Nathan, J. D., et al.
Publicado: (2001)

Intra-abdominal desmoplastic small round cell tumor.
por: Nathan, J. D., et al.
Publicado: (1999)

Intra-abdominal desmoplastic small round cell tumor
por: Thandassery, Ragesh Babu, et al.
Publicado: (2014)

Primary desmoplastic small round cell tumor of the duodenum
por: Liu, Qi, et al.
Publicado: (2014)

Immunotherapy and Radioimmunotherapy for Desmoplastic Small Round Cell Tumor
por: Espinosa-Cotton, Madelyn, et al.
Publicado: (2021)

The Small Round Cell Sarcomas Complexities and Desmoplastic Presentation
por: Domanski, Henryk A.
Publicado: (2022)

Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations
por: Mannarino, Laura, et al.
Publicado: (2022)

Desmoplastic small round cell tumour: Cytological and immunocytochemical features
por: Granja, Nara M, et al.
Publicado: (2005)

Desmoplastic small round cell tumor: postoperative retroperitoneal mass
por: Shen, Colette J., et al.
Publicado: (2016)

Efficacy of ONC201 in Desmoplastic Small Round Cell Tumor()
por: Hayes-Jordan, Andrea A., et al.
Publicado: (2018)

A nationwide analysis of desmoplastic small round cell tumor
por: Xiang, Tao, et al.
Publicado: (2020)

A Classic Presentation of Desmoplastic Small Round Cell Tumor
por: Matute, Gustavo, et al.
Publicado: (2021)

Inhibition of tumor‐associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti‐PD‐1 therapy
por: Belgiovine, Cristina, et al.
Publicado: (2021)

Regional and temporal heterogeneity of epithelial ovarian cancer tumor biopsies: implications for therapeutic strategies
por: Paracchini, Lara, et al.
Publicado: (2016)

Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines
por: Ávila-Arroyo, Sonia, et al.
Publicado: (2015)

Clinical Characteristics and Outcomes of Pediatric Patients with Desmoplastic Small Round Cell Tumor
por: Bent, Melissa A., et al.
Publicado: (2016)

Desmoplastic Small Round Cell Tumor: Current Management and Recent Findings
por: Dufresne, Armelle, et al.
Publicado: (2012)

Desmoplastic small round cell tumour: the radiological, pathological and clinical features
por: Thomas, Robert, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_sts5o04reno0128f6ffs5ci2o5