The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8(+) T cells in the tumor microenvironment

Although the presence of tumor-infiltrating lymphocytes (TILs) indicates an endogenous antitumor response, immune regulatory pathways can subvert the effector phase and enable tumor escape. Negative regulatory pathways include extrinsic suppression mechanisms, but also a T cell–intrinsic dysfunction...

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Detalles Bibliográficos
Autores principales: Williams, Jason B., Horton, Brendan L., Zheng, Yan, Duan, Yukan, Powell, Jonathan D., Gajewski, Thomas F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294847/
https://www.ncbi.nlm.nih.gov/pubmed/28115575
http://dx.doi.org/10.1084/jem.20160485

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294847/
https://www.ncbi.nlm.nih.gov/pubmed/28115575
http://dx.doi.org/10.1084/jem.20160485

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