Peptidylarginine deiminase 4 promotes age-related organ fibrosis

Aging promotes inflammation, a process contributing to fibrosis and decline in organ function. The release of neutrophil extracellular traps (NETs [NETosis]), orchestrated by peptidylarginine deiminase 4 (PAD4), damages organs in acute inflammatory models. We determined that NETosis is more prevalen...

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Detalles Bibliográficos
Autores principales: Martinod, Kimberly, Witsch, Thilo, Erpenbeck, Luise, Savchenko, Alexander, Hayashi, Hideki, Cherpokova, Deya, Gallant, Maureen, Mauler, Maximilian, Cifuni, Stephen M., Wagner, Denisa D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294849/
https://www.ncbi.nlm.nih.gov/pubmed/28031479
http://dx.doi.org/10.1084/jem.20160530

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294849/
https://www.ncbi.nlm.nih.gov/pubmed/28031479
http://dx.doi.org/10.1084/jem.20160530

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