TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity

MDA5 plays a critical role in antiviral innate immunity by functioning as a cytoplasmic double-stranded RNA sensor that can activate type I interferon signaling pathways, but the mechanism for the activation of MDA5 is poorly understood. Here, we show that TRIM65 specifically interacts with MDA5 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Lang, Xueting, Tang, Tiantian, Jin, Tengchuan, Ding, Chen, Zhou, Rongbin, Jiang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294850/
https://www.ncbi.nlm.nih.gov/pubmed/28031478
http://dx.doi.org/10.1084/jem.20160592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294850/
https://www.ncbi.nlm.nih.gov/pubmed/28031478
http://dx.doi.org/10.1084/jem.20160592

Ejemplares similares