Pharmacologic inhibition of Hsp90 to prevent GLT-1 degradation as an effective therapy for epilepsy

The glutamate transporter GLT-1 is critical for the maintenance of low interstitial glutamate concentrations. Loss of GLT-1 is commonly observed in neurological disorders, including temporal lobe epilepsy (TLE). Despite the hypothesis that targeting the mechanisms of GLT-1 deficiency may be a novel...

Descripción completa

Detalles Bibliográficos
Autores principales: Sha, Longze, Wang, Xueqin, Li, Jing, Shi, Xinze, Wu, Liwen, Shen, Yan, Xu, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294855/
https://www.ncbi.nlm.nih.gov/pubmed/28028152
http://dx.doi.org/10.1084/jem.20160667

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294855/
https://www.ncbi.nlm.nih.gov/pubmed/28028152
http://dx.doi.org/10.1084/jem.20160667

Ejemplares similares