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Efficient confidence limits for adaptive one-arm two-stage clinical trials with binary endpoints
BACKGROUND: Recently, several adaptive one-arm two-stage designs have been developed by fully using the information from previous stages to reduce the expected sample size in clinical trials with binary endpoints as primary outcome. It is important to compute exact confidence limits for these studie...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294881/ https://www.ncbi.nlm.nih.gov/pubmed/28166741 http://dx.doi.org/10.1186/s12874-017-0297-5 |