Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1

End processing at DNA double strand breaks (DSB) is a decisive step in repair pathway selection. Here, we investigated the role of 53BP1/RIF1 in limiting BRCA1/CtIP-mediated end resection to control DSB repair pathway choice. ATM orchestrates this process through 53BP1 phosphorylation to promote RIF...

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Detalles Bibliográficos
Autores principales: Bakr, Ali, Köcher, Sabrina, Volquardsen, Jennifer, Petersen, Cordula, Borgmann, Kerstin, Dikomey, Ekkehard, Rothkamm, Kai, Mansour, Wael Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295381/
https://www.ncbi.nlm.nih.gov/pubmed/27494840
http://dx.doi.org/10.18632/oncotarget.11023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295381/
https://www.ncbi.nlm.nih.gov/pubmed/27494840
http://dx.doi.org/10.18632/oncotarget.11023

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