Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis

Overexpression and increased activity of the small Rho GTPase Rac1 has been linked to squamous cell carcinoma of the epidermis and mucosa in humans. Targeted deletion of Rac1 or inhibition of Rac1 activity in epidermal keratinocytes reduced papilloma formation in a chemical skin carcinogenesis mouse...

Descripción completa

Detalles Bibliográficos
Autores principales: Deshmukh, Jayesh, Pofahl, Ruth, Pfister, Herbert, Haase, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295394/
https://www.ncbi.nlm.nih.gov/pubmed/27506937
http://dx.doi.org/10.18632/oncotarget.11069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295394/
https://www.ncbi.nlm.nih.gov/pubmed/27506937
http://dx.doi.org/10.18632/oncotarget.11069

Ejemplares similares