Structural basis for exploring the allosteric inhibition of human kidney type glutaminase

Cancer cells employ glutaminolysis to provide a source of intermediates for their upregulated biosynthetic needs. Glutaminase, which catalyzes the conversion of glutamine to glutamate, is gaining increasing attention as a potential drug target. Small-molecule inhibitors such as BPTES and CB-839, whi...

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Detalles Bibliográficos
Autores principales: Ramachandran, Sarath, Pan, Catherine Qiurong, Zimmermann, Sarah C., Duvall, Bridget, Tsukamoto, Takashi, Low, Boon Chuan, Sivaraman, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295402/
https://www.ncbi.nlm.nih.gov/pubmed/27462863
http://dx.doi.org/10.18632/oncotarget.10791

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295402/
https://www.ncbi.nlm.nih.gov/pubmed/27462863
http://dx.doi.org/10.18632/oncotarget.10791

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