Ligand activated progesterone receptor B drives autophagy-senescence transition through a Beclin-1/Bcl-2 dependent mechanism in human breast cancer cells

Loss of progesterone-receptors (PR) expression is associated with breast cancer progression. Herein we provide evidence that OHPg/PR-B through Beclin-1 evoke autophagy-senescence transition, in breast cancer cells. Specifically, OHPg increases Beclin-1 expression through a transcriptional mechanism...

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Detalles Bibliográficos
Autores principales: De Amicis, Francesca, Guido, Carmela, Santoro, Marta, Giordano, Francesca, Donà, Ada, Rizza, Pietro, Pellegrino, Michele, Perrotta, Ida, Bonofiglio, Daniela, Sisci, Diego, Panno, Maria Luisa, Tramontano, Donatella, Aquila, Saveria, Andò, Sebastiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295403/
https://www.ncbi.nlm.nih.gov/pubmed/27462784
http://dx.doi.org/10.18632/oncotarget.10799

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295403/
https://www.ncbi.nlm.nih.gov/pubmed/27462784
http://dx.doi.org/10.18632/oncotarget.10799

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