Cargando…

Ligand activated progesterone receptor B drives autophagy-senescence transition through a Beclin-1/Bcl-2 dependent mechanism in human breast cancer cells

Loss of progesterone-receptors (PR) expression is associated with breast cancer progression. Herein we provide evidence that OHPg/PR-B through Beclin-1 evoke autophagy-senescence transition, in breast cancer cells. Specifically, OHPg increases Beclin-1 expression through a transcriptional mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales:	De Amicis, Francesca, Guido, Carmela, Santoro, Marta, Giordano, Francesca, Donà, Ada, Rizza, Pietro, Pellegrino, Michele, Perrotta, Ida, Bonofiglio, Daniela, Sisci, Diego, Panno, Maria Luisa, Tramontano, Donatella, Aquila, Saveria, Andò, Sebastiano
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295403/ https://www.ncbi.nlm.nih.gov/pubmed/27462784 http://dx.doi.org/10.18632/oncotarget.10799

Ejemplares similares

Progesterone Receptor B signaling Reduces Breast Cancer Cell Aggressiveness: Role of Cyclin-D1/Cdk4 Mediating Paxillin Phosphorylation
por: Montalto, Francesca Ida, et al.
Publicado: (2019)

A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells
por: De Amicis, Francesca, et al.
Publicado: (2014)

Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells
por: De Amicis, Francesca, et al.
Publicado: (2015)

Androgens downregulate miR-21 expression in breast cancer cells underlining the protective role of androgen receptor
por: Casaburi, Ivan, et al.
Publicado: (2016)

The Tumor Suppressor PTEN as Molecular Switch Node Regulating Cell Metabolism and Autophagy: Implications in Immune System and Tumor Microenvironment
por: Aquila, Saveria, et al.
Publicado: (2020)

FSH-R Human Early Male Genital Tract, Testicular Tumors and Sperm: Its Involvement in Testicular Disorders
por: Panza, Salvatore, et al.
Publicado: (2020)

Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism
por: Aquila, Saveria, et al.
Publicado: (2009)

FoxO3a as a Positive Prognostic Marker and a Therapeutic Target in Tamoxifen-Resistant Breast Cancer
por: Pellegrino, Michele, et al.
Publicado: (2019)

Estrogen receptor beta as a novel target of androgen receptor action in breast cancer cell lines
por: Rizza, Pietro, et al.
Publicado: (2014)

Nutraceuticals in the Mediterranean Diet: Potential Avenues for Breast Cancer Treatment
por: Augimeri, Giuseppina, et al.
Publicado: (2021)

Nitric oxide involvement in the acrosome reaction triggered by leptin in pig sperm
por: Aquila, Saveria, et al.
Publicado: (2011)

Cdk4 Regulates Glioblastoma Cell Invasion and Stemness and Is Target of a Notch Inhibitor Plus Resveratrol Combined Treatment
por: Giordano, Francesca, et al.
Publicado: (2023)

Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism
por: Zhang, Lindong, et al.
Publicado: (2019)

Ligand-activated PPARγ downregulates CXCR4 gene expression through a novel identified PPAR response element and inhibits breast cancer progression
por: Rovito, Daniela, et al.
Publicado: (2016)

Regulation of the Autophagic Bcl-2/Beclin 1 Interaction
por: Decuypere, Jean-Paul, et al.
Publicado: (2012)

DAX-1, as an androgen-target gene, inhibits aromatase expression: a novel mechanism blocking estrogen-dependent breast cancer cell proliferation
por: Lanzino, M, et al.
Publicado: (2013)

AIB1 sequestration by androgen receptor inhibits estrogen-dependent cyclin D1 expression in breast cancer cells
por: De Amicis, Francesca, et al.
Publicado: (2019)

Mst1 inhibits autophagy by promoting Beclin1-Bcl-2 interaction
por: Maejima, Yasuhiro, et al.
Publicado: (2013)

The Omega-3 Docosahexaenoyl Ethanolamide Reduces CCL5 Secretion in Triple Negative Breast Cancer Cells Affecting Tumor Progression and Macrophage Recruitment
por: Augimeri, Giuseppina, et al.
Publicado: (2023)

Novel Insights into the Antagonistic Effects of Losartan against Angiotensin II/AGTR1 Signaling in Glioblastoma Cells
por: Panza, Salvatore, et al.
Publicado: (2021)

Modulating Tumor-Associated Macrophage Polarization by Synthetic and Natural PPARγ Ligands as a Potential Target in Breast Cancer
por: Gionfriddo, Giulia, et al.
Publicado: (2020)

Expression of Concern: Progesterone receptor antagonist provides palliative effects for uterine leiomyoma through a Bcl-2/Beclin1-dependent mechanism
Publicado: (2021)

FoxO3a Inhibits Tamoxifen-Resistant Breast Cancer Progression by Inducing Integrin α5 Expression
por: Ricci, Elena, et al.
Publicado: (2022)

LPL, FNDC5 and PPARγ gene polymorphisms related to body composition parameters and lipid metabolic profile in adolescents from Southern Italy
por: Perrone, Benedetta, et al.
Publicado: (2022)

Impact of Vigorous-Intensity Physical Activity on Body Composition Parameters, Lipid Profile Markers, and Irisin Levels in Adolescents: A Cross-Sectional Study
por: Morelli, Catia, et al.
Publicado: (2020)

Structural insights for selective disruption of Beclin 1 binding to Bcl-2
por: Pan, Yun-Zu, et al.
Publicado: (2023)

Activated FXR Inhibits Leptin Signaling and Counteracts Tumor-promoting Activities of Cancer-Associated Fibroblasts in Breast Malignancy
por: Giordano, Cinzia, et al.
Publicado: (2016)

Evidence for Enhanced Exosome Production in Aromatase Inhibitor-Resistant Breast Cancer Cells
por: Augimeri, Giuseppina, et al.
Publicado: (2020)

Impaired Autophagy in Krabbe Disease: The Role of BCL2 and Beclin-1 Phosphorylation
por: Papini, Nadia, et al.
Publicado: (2023)

The Role of Oxidative Stress and Autophagy in Atherosclerosis
por: Perrotta, Ida, et al.
Publicado: (2015)

Androgens Modulate Bcl-2 Agonist of Cell Death (BAD) Expression and Function in Breast Cancer Cells
por: Morelli, Catia, et al.
Publicado: (2023)

Unraveling the Role of Adiponectin Receptors in Obesity-Related Breast Cancer
por: Naimo, Giuseppina Daniela, et al.
Publicado: (2023)

Disruption of the beclin 1/Bcl-2 autophagy regulatory complex promotes longevity in mice
por: Fernández, Álvaro F., et al.
Publicado: (2018)

The Multifaceted Mechanism of Leptin Signaling within Tumor Microenvironment in Driving Breast Cancer Growth and Progression
por: Andò, Sebastiano, et al.
Publicado: (2014)

Phosphodiesterase type 5 and cancers: progress and challenges
por: Barone, Ines, et al.
Publicado: (2017)

Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells—identification of a novel androgen response element
por: Lanzino, Marilena, et al.
Publicado: (2010)

Potential Antioxidant and Anti-Inflammatory Properties of Serum from Healthy Adolescents with Optimal Mediterranean Diet Adherence: Findings from DIMENU Cross-Sectional Study
por: Augimeri, Giuseppina, et al.
Publicado: (2021)

Cytochrome P450 aromatase expression in human seminoma
por: Rago, Vittoria, et al.
Publicado: (2005)

Apoptosis blocks Beclin 1-dependent autophagosome synthesis – an effect rescued by Bcl-xL
por: Luo, S, et al.
Publicado: (2009)

Characterization of apoptosis and autophagy through Bcl-2 and Beclin-1 immunoexpression in gestational trophoblastic disease
por: Wargasetia, Teresa Liliana, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_kndtai0srhiueoq4jhq5e8n70f