ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance

The CDK inhibitor SNS-032 had previously exerted promising anti-neuroblastoma activity via CDK7 and 9 inhibition. ABCB1 expression was identified as major determinant of SNS-032 resistance. Here, we investigated the role of ABCB1 in acquired SNS-032 resistance. In contrast to ABCB1-expressing UKF-NB...

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Detalles Bibliográficos
Autores principales: Löschmann, Nadine, Michaelis, Martin, Rothweiler, Florian, Voges, Yvonne, Balónová, Barbora, Blight, Barry A., Cinatl, Jindrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295411/
https://www.ncbi.nlm.nih.gov/pubmed/27517323
http://dx.doi.org/10.18632/oncotarget.11160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295411/
https://www.ncbi.nlm.nih.gov/pubmed/27517323
http://dx.doi.org/10.18632/oncotarget.11160

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