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ABCB1 as predominant resistance mechanism in cells with acquired SNS-032 resistance

The CDK inhibitor SNS-032 had previously exerted promising anti-neuroblastoma activity via CDK7 and 9 inhibition. ABCB1 expression was identified as major determinant of SNS-032 resistance. Here, we investigated the role of ABCB1 in acquired SNS-032 resistance. In contrast to ABCB1-expressing UKF-NB...

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Detalles Bibliográficos
Autores principales:	Löschmann, Nadine, Michaelis, Martin, Rothweiler, Florian, Voges, Yvonne, Balónová, Barbora, Blight, Barry A., Cinatl, Jindrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295411/ https://www.ncbi.nlm.nih.gov/pubmed/27517323 http://dx.doi.org/10.18632/oncotarget.11160

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