Nur77 deficiency in mice accelerates tumor invasion and metastasis by facilitating TNFα secretion and lowering CSF-1R expression

Nur77, an orphan member of the nuclear receptor superfamily, plays critical roles in inflammation and immunity. However, the role of Nur77 in tumor microenvironment remains elusive. Results showed that deletion of Nur77 strikingly enhanced tumor metastasis compared to WT mice. Additionally, compared...

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Detalles Bibliográficos
Autores principales: Li, Xiu-Ming, Wang, Jing-Ru, Shen, Tong, Gao, Shang-Shang, He, Xiao-Shun, Li, Jiang-Nan, Yang, Tian-Yu, Zhang, Shen, Gan, Wen-Juan, Li, Jian-Ming, Wu, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295676/
https://www.ncbi.nlm.nih.gov/pubmed/28170411
http://dx.doi.org/10.1371/journal.pone.0171347

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295676/
https://www.ncbi.nlm.nih.gov/pubmed/28170411
http://dx.doi.org/10.1371/journal.pone.0171347

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