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Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats

VEGF inhibitors, including receptor tyrosine kinase inhibitors, are used as adjunct therapies in a number of cancer treatments. An emerging issue with these drugs is that most cause hypertension. To gain insight into the physiological mechanisms involved, we evaluated their regional hemodynamic effe...

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Detalles Bibliográficos
Autores principales: Carter, Joanne J., Fretwell, Laurice V., Woolard, Jeanette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295730/
https://www.ncbi.nlm.nih.gov/pubmed/27986807
http://dx.doi.org/10.1096/fj.201600749R