Role of ID Proteins in BMP4 Inhibition of Profibrotic Effects of TGF-β2 in Human TM Cells

PURPOSE: Increased expression of TGF-β2 in primary open-angle glaucoma (POAG) aqueous humor (AH) and trabecular meshwork (TM) causes deposition of extracellular matrix (ECM) in the TM and elevated IOP. Bone morphogenetic proteins (BMPs) regulate TGF-β2–induced ECM production. The underlying mechanis...

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Detalles Bibliográficos
Autores principales: Mody, Avani A., Wordinger, Robert J., Clark, Abbot F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Glaucoma
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295782/
https://www.ncbi.nlm.nih.gov/pubmed/28159972
http://dx.doi.org/10.1167/iovs.16-20472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295782/
https://www.ncbi.nlm.nih.gov/pubmed/28159972
http://dx.doi.org/10.1167/iovs.16-20472

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