Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study

Griseofulvin, an orally active antifungal drug used to treat dermatophyte infections, has a secondary effect of inducing cytochrome P450-mediated production of N-methyl protoporphyrin IX (N-MPP). N-MPP is a potent competitive inhibitor of the heme biosynthetic-enzyme ferrochelatase, and inhibits the...

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Detalles Bibliográficos
Autores principales: Smith, Clare M., Jerkovic, Ante, Truong, Thy Thuc, Foote, Simon J., McCarthy, James S., McMorran, Brendan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296727/
https://www.ncbi.nlm.nih.gov/pubmed/28176804
http://dx.doi.org/10.1038/srep41975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296727/
https://www.ncbi.nlm.nih.gov/pubmed/28176804
http://dx.doi.org/10.1038/srep41975

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