N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment

N,N-Dimethylacetamide (DMA) is a water-miscible solvent, FDA approved as excipient and therefore widely used as drug-delivery vehicle. As such, DMA should be devoid of any bioactivity. Here we report that DMA is epigenetically active since it binds bromodomains and inhibits osteoclastogenesis and in...

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Detalles Bibliográficos
Autores principales: Ghayor, Chafik, Gjoksi, Bebeka, Dong, Jing, Siegenthaler, Barbara, Caflisch, Amedeo, Weber, Franz E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296751/
https://www.ncbi.nlm.nih.gov/pubmed/28176838
http://dx.doi.org/10.1038/srep42108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296751/
https://www.ncbi.nlm.nih.gov/pubmed/28176838
http://dx.doi.org/10.1038/srep42108

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