Cargando…

N,N Dimethylacetamide a drug excipient that acts as bromodomain ligand for osteoporosis treatment

N,N-Dimethylacetamide (DMA) is a water-miscible solvent, FDA approved as excipient and therefore widely used as drug-delivery vehicle. As such, DMA should be devoid of any bioactivity. Here we report that DMA is epigenetically active since it binds bromodomains and inhibits osteoclastogenesis and in...

Descripción completa

Detalles Bibliográficos
Autores principales: Ghayor, Chafik, Gjoksi, Bebeka, Dong, Jing, Siegenthaler, Barbara, Caflisch, Amedeo, Weber, Franz E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296751/
https://www.ncbi.nlm.nih.gov/pubmed/28176838
http://dx.doi.org/10.1038/srep42108

Ejemplares similares