Motivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.Htt(Q111/+) model of Huntington’s disease

We investigated the appearance and progression of disease-relevant signs in the B6.Htt(Q111/+) mouse, a genetically precise model of the mutation that causes Huntington’s disease (HD). We find that B6.Htt(Q111/+) mice are healthy, show no overt signs of central or peripheral inflammation, and no gro...

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Detalles Bibliográficos
Autores principales: Bragg, Robert M., Coffey, Sydney R., Weston, Rory M., Ament, Seth A., Cantle, Jeffrey P., Minnig, Shawn, Funk, Cory C., Shuttleworth, Dominic D., Woods, Emily L., Sullivan, Bonnie R., Jones, Lindsey, Glickenhaus, Anne, Anderson, John S., Anderson, Michael D., Dunnett, Stephen B., Wheeler, Vanessa C., MacDonald, Marcy E., Brooks, Simon P., Price, Nathan D., Carroll, Jeffrey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296868/
https://www.ncbi.nlm.nih.gov/pubmed/28176805
http://dx.doi.org/10.1038/srep41570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296868/
https://www.ncbi.nlm.nih.gov/pubmed/28176805
http://dx.doi.org/10.1038/srep41570

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