Distribution bias analysis of germline and somatic single-nucleotide variations that impact protein functional site and neighboring amino acids

Single nucleotide variations (SNVs) can result in loss or gain of protein functional sites. We analyzed the effects of SNVs on enzyme active sites, ligand binding sites, and various types of post translational modification (PTM) sites. We found that, for most types of protein functional sites, the S...

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Detalles Bibliográficos
Autores principales: Pan, Yang, Yan, Cheng, Hu, Yu, Fan, Yu, Pan, Qing, Wan, Quan, Torcivia-Rodriguez, John, Mazumder, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296879/
https://www.ncbi.nlm.nih.gov/pubmed/28176830
http://dx.doi.org/10.1038/srep42169

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296879/
https://www.ncbi.nlm.nih.gov/pubmed/28176830
http://dx.doi.org/10.1038/srep42169

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