Intestinal cancer stem cells marked by Bmi1 or Lgr5 expression contribute to tumor propagation via clonal expansion

Although the existence of cancer stem cells in intestine tumors has been suggested, direct evidence has not been yet provided. Here, we showed, using the multicolor lineage-tracing method and mouse models of intestinal adenocarcinoma and adenoma that Bmi1- or Lgr5- positive tumorigenic cells clonall...

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Detalles Bibliográficos
Autores principales: Yanai, Hirotsugu, Atsumi, Naho, Tanaka, Toshihiro, Nakamura, Naohiro, Komai, Yoshihiro, Omachi, Taichi, Tanaka, Kiyomichi, Ishigaki, Kazuhiko, Saiga, Kazuho, Ohsugi, Haruyuki, Tokuyama, Yoko, Imahashi, Yuki, Ohe, Shuichi, Hisha, Hiroko, Yoshida, Naoko, Kumano, Keiki, Kon, Masanori, Ueno, Hiroo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296906/
https://www.ncbi.nlm.nih.gov/pubmed/28176811
http://dx.doi.org/10.1038/srep41838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296906/
https://www.ncbi.nlm.nih.gov/pubmed/28176811
http://dx.doi.org/10.1038/srep41838

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