Mechanisms responsible for the synergistic antileukemic interactions between ATR inhibition and cytarabine in acute myeloid leukemia cells

Acute myeloid leukemia (AML) continues to be a challenging disease to treat, thus new treatment strategies are needed. In this study, we investigated the antileukemic effects of ATR inhibition alone or combined with cytarabine in AML cells. Treatment with the ATR-selective inhibitor AZ20 caused prol...

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Detalles Bibliográficos
Autores principales: Ma, Jun, Li, Xinyu, Su, Yongwei, Zhao, Jianyun, Luedtke, Daniel A., Epshteyn, Valeria, Edwards, Holly, Wang, Guan, Wang, Zhihong, Chu, Roland, Taub, Jeffrey W., Lin, Hai, Wang, Yue, Ge, Yubin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296912/
https://www.ncbi.nlm.nih.gov/pubmed/28176818
http://dx.doi.org/10.1038/srep41950

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296912/
https://www.ncbi.nlm.nih.gov/pubmed/28176818
http://dx.doi.org/10.1038/srep41950

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