Cargando…

Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer

BACKGROUND: Protease activated receptor (PAR)-1 expression is increased in a variety of tumor cells. In preclinical models, tumor cell PAR-1 appeared to be involved in the regulation of lung tumor growth and metastasis; however the role of PAR-1 in the lung tumor microenvironment, which is emerging...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Cong, Majoor, Christof J., Roelofs, Joris J. T. H., de Kruif, Martijn D., Horlings, Hugo M., Borensztajn, Keren, Spek, C. Arnold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297223/ https://www.ncbi.nlm.nih.gov/pubmed/28173772 http://dx.doi.org/10.1186/s12885-017-3081-3

Ejemplares similares

Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis
por: Lin, Cong, et al.
Publicado: (2015)

Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis
por: Lin, Cong, et al.
Publicado: (2015)

The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm
por: Borensztajn, Keren, et al.
Publicado: (2010)

CCAAT/enhancer binding protein delta (C/EBPδ) deficiency does not affect bleomycin-induced pulmonary fibrosis
por: JanWillem, Duitman, et al.
Publicado: (2018)

Role of Serine Proteases at the Tumor-Stroma Interface
por: Tagirasa, Ravichandra, et al.
Publicado: (2022)

PCSK6: The Endogenous PAR-1 Agonist Driving Pulmonary Fibrosis?
por: Spek, C. Arnold, et al.
Publicado: (2023)

High endogenous activated protein C levels attenuates bleomycin‐induced pulmonary fibrosis
por: Lin, Cong, et al.
Publicado: (2016)

Protease-Activated Receptor (PAR)2, but Not PAR1, Is Involved in Collateral Formation and Anti-Inflammatory Monocyte Polarization in a Mouse Hind Limb Ischemia Model
por: van den Hengel, Lisa G., et al.
Publicado: (2013)

Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation
por: Duitman, JanWillem, et al.
Publicado: (2021)

Radiotherapy and the Tumor Stroma: The Importance of Dose and Fractionation
por: Hellevik, Turid, et al.
Publicado: (2014)

C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC
por: Hartl, Leonie, et al.
Publicado: (2023)

Chemical Tools to Image the Activity of PAR-Cleaving Proteases
por: Lee, Irene Y., et al.
Publicado: (2023)

Prostate cancer stroma: an important factor in cancer growth and progression
por: Krušlin, Božo, et al.
Publicado: (2015)

Humanizing the Protease-Activated Receptor (PAR) Expression Profile in Mouse Platelets by Knocking PAR1 into the Par3 Locus Reveals PAR1 Expression Is Not Tolerated in Mouse Platelets
por: French, Shauna L., et al.
Publicado: (2016)

Importance of lysosomal cysteine proteases in lung disease
por: Wolters, Paul J, et al.
Publicado: (2000)

Periostin and tumor-stroma interactions in non-small cell lung cancer
por: Nitsche, Ulrich, et al.
Publicado: (2016)

Fibroblasts: the missing link between fibrotic lung diseases of different etiologies?
por: Crestani, Bruno, et al.
Publicado: (2013)

Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases
por: Heuberger, Dorothea M., et al.
Publicado: (2019)

Thrombin-mediated vasculogenic mimicry: important lessons to improve anticoagulant therapy of selected cancer patients
por: Spek, C. Arnold
Publicado: (2020)

Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner
por: Waasdorp, Maaike, et al.
Publicado: (2017)

Development and Evaluation of Small Peptidomimetic Ligands to Protease-Activated Receptor-2 (PAR(2)) through the Use of Lipid Tethering
por: Boitano, Scott, et al.
Publicado: (2014)

Correction to: protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases
por: Heuberger, Dorothea M., et al.
Publicado: (2019)

RED CELL STROMA IN DOGS : STROMA PROTEIN AND STROMA LIPIDES VARY IN DIFFERENT TYPES OF ANEMIA
por: Robscheit-Robbins, F. S., et al.
Publicado: (1955)

Protease-activated receptor-1 deficiency protects against streptozotocin-induced diabetic nephropathy in mice
por: Waasdorp, Maaike, et al.
Publicado: (2016)

Histone 2B Facilitates Plasminogen-Enhanced Endothelial Migration through Protease-Activated Receptor 1 (PAR1) and Protease-Activated Receptor 2 (PAR2)
por: Das, Mitali, et al.
Publicado: (2022)

Protease-activated receptors (PARs)—biology and role in cancer invasion and metastasis
por: Wojtukiewicz, Marek Z., et al.
Publicado: (2015)

Tic40 is important for reinsertion of proteins from the chloroplast stroma into the inner membrane
por: Chiu, Chi-Chou, et al.
Publicado: (2008)

The expression pattern of matrix-producing tumor stroma is of prognostic importance in breast cancer
por: Winslow, Sofia, et al.
Publicado: (2016)

T cells in pancreatic cancer stroma: Tryptophan metabolism plays an important role in immunoregulation
por: Yang, Ting, et al.
Publicado: (2023)

Chemokine receptor expression in tumour islets and stroma in non-small cell lung cancer
por: Ohri, Chandra M, et al.
Publicado: (2010)

Protease-activated receptor-1 impairs host defense in murine pneumococcal pneumonia: a controlled laboratory study
por: Schouten, Marcel, et al.
Publicado: (2012)

PAR1 signaling on tumor cells limits tumor growth by maintaining a mesenchymal phenotype in pancreatic cancer
por: Tekin, Cansu, et al.
Publicado: (2018)

Identification of distinct miRNA target regulation between breast cancer molecular subtypes using AGO2-PAR-CLIP and patient datasets
por: Farazi, Thalia A, et al.
Publicado: (2014)

Macrophage-secreted MMP9 induces mesenchymal transition in pancreatic cancer cells via PAR1 activation
por: Tekin, Cansu, et al.
Publicado: (2020)

Emerging Roles of Protease-Activated Receptors (PARs) in the Modulation of Synaptic Transmission and Plasticity
por: Price, Rachel, et al.
Publicado: (2021)

The importance of CXCR4 expression in tumor stroma as a potential biomarker in pancreatic cancer
por: Bodoque-Villar, Raquel, et al.
Publicado: (2023)

P1329: REGIONAL COMPARTMENTALIZATION OF THE BONE MARROW STROMA IS IMPORTANT FOR RESPONSES TO INFLAMMATION AND CANCER
por: Swann, James, et al.
Publicado: (2023)

The prognostic value of tumor-stroma ratio and a newly developed computer-aided quantitative analysis of routine H&E slides in high-grade serous ovarian cancer
por: van wagensveld, lilian, et al.
Publicado: (2023)

Antithrombotic Effects of Combined PAR (Protease-Activated Receptor)-4 Antagonism and Factor Xa Inhibition
por: Meah, Mohammed N., et al.
Publicado: (2020)

Complement factor C4a does not activate protease‐activated receptor 1 (PAR1) or PAR4 on human platelets
por: Han, Xu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_paubt7d3rqai0ln6aommtunt63