Quantitative characterization of the mechanism of action and impact of a ‘proteolysis-permitting’ anti-PCSK9 antibody

A recent report described a novel mechanism of action for an anti-proprotein convertase subtilisin-kexin type 9 (PCSK9) monoclonal antibody (LY3015014, or LY), wherein the antibody has improved potency and duration of action due to the PCSK9 epitope for LY binding. Unlike other antibodies, proteolys...

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Detalles Bibliográficos
Autores principales: Hansen, Ryan J., Berna, Michael J., Sperry, Andrea E., Beyer, Thomas P., Wroblewski, Victor J., Schroeder, Krista M., Eacho, Patrick I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297531/
https://www.ncbi.nlm.nih.gov/pubmed/27981884
http://dx.doi.org/10.1080/19420862.2016.1270490

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297531/
https://www.ncbi.nlm.nih.gov/pubmed/27981884
http://dx.doi.org/10.1080/19420862.2016.1270490

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