In Vitro Biotransformation of Two Human CYP3A Probe Substrates and Their Inhibition during Early Zebrafish Development

At present, the zebrafish embryo is increasingly used as an alternative animal model to screen for developmental toxicity after exposure to xenobiotics. Since zebrafish embryos depend on their own drug-metabolizing capacity, knowledge of their intrinsic biotransformation is pivotal in order to corre...

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Detalles Bibliográficos
Autores principales: Verbueken, Evy, Alsop, Derek, Saad, Moayad A., Pype, Casper, Van Peer, Els M., Casteleyn, Christophe R., Van Ginneken, Chris J., Wilson, Joanna, Van Cruchten, Steven J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297846/
https://www.ncbi.nlm.nih.gov/pubmed/28117738
http://dx.doi.org/10.3390/ijms18010217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297846/
https://www.ncbi.nlm.nih.gov/pubmed/28117738
http://dx.doi.org/10.3390/ijms18010217

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