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Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry
There are more H atoms than any other type of atom in an X-ray crystal structure of a protein–ligand complex, but as H atoms only have one electron they diffract X-rays weakly and are ‘hard to see’. The positions of many H atoms can be inferred by our chemical knowledge, and such H atoms can be adde...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297916/ https://www.ncbi.nlm.nih.gov/pubmed/28177309 http://dx.doi.org/10.1107/S2059798316020283 |