Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry

The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. This chemistry is likely to be broadly applicable to the synthesis of o...

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Detalles Bibliográficos
Autores principales: Kong, A., Mancheno, D. E., Boudet, N., Delgado, R., Andreansky, E. S., Blakey, S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297967/
https://www.ncbi.nlm.nih.gov/pubmed/28451219
http://dx.doi.org/10.1039/c6sc03578g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297967/
https://www.ncbi.nlm.nih.gov/pubmed/28451219
http://dx.doi.org/10.1039/c6sc03578g

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