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Total synthesis of malagashanine: a chloroquine potentiating indole alkaloid with unusual stereochemistry
The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. This chemistry is likely to be broadly applicable to the synthesis of o...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297967/ https://www.ncbi.nlm.nih.gov/pubmed/28451219 http://dx.doi.org/10.1039/c6sc03578g |