Structural Simplification of Bedaquiline: the Discovery of 3‐(4‐(N,N‐Dimethylaminomethyl)phenyl)quinoline‐Derived Antitubercular Lead Compounds

Bedaquiline (BDQ) is a novel and highly potent last‐line antituberculosis drug that was approved by the US FDA in 2013. Owing to its stereo‐structural complexity, chemical synthesis and compound optimization are rather difficult and expensive. This study describes the structural simplification of be...

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Detalles Bibliográficos
Autores principales: He, Chunxian, Preiss, Laura, Wang, Bin, Fu, Lei, Wen, Hui, Zhang, Xiang, Cui, Huaqing, Meier, Thomas, Yin, Dali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298006/
https://www.ncbi.nlm.nih.gov/pubmed/27792278
http://dx.doi.org/10.1002/cmdc.201600441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298006/
https://www.ncbi.nlm.nih.gov/pubmed/27792278
http://dx.doi.org/10.1002/cmdc.201600441

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